Article continues below advertisementOprah Winfrey got honest about her use of GLP-1 medications for weight loss, describing it as a trial-and-error journey. After years of struggling with her weight, the former talk show host, 71, turned to GLP-1s in 2023, but decided only six months later to try to "beat the medication" after her confession caused backlash.Article continues below advertisementOprah Winfrey Wanted to Test the 'Science'Source: MEGAOprah Winfrey quit GLP-1 medication 'cold turkey' and gained 20 pounds."I said, 'I'm going to see if the science is right.