Article continues below advertisementOprah Winfrey spent years feeling shame and blaming herself for being overweight - until she was saved by GLP-1 drugs.In a new interview published Tuesday, December 30, the former talk show star opened up about the public humiliation and internal struggles she endured for decades over her weight while thanking newfound medications for helping shift her understanding of obesity.Despite projecting confidence throughout her career, the legendary television personality admitted she always felt insecure when it came to her body.