Kathy Griffin is opening up about a painful chapter of her life involving her eldest brother, Kenneth. In a recent YouTube video, Griffin, 65, mourned the deaths of Rob Reiner and wife Michele Singer Reiner, whose son Nick stands accused of their murder, and relayed details about her own family's struggles with Kenneth, who died in 2001. (Griffin is the youngest of five children, growing up with brothers Kenneth, Gary and John, and sister Joyce.) "I'm going to open up to you about something now that I haven't really talked about since my first book.