Meg Ryan is mourning When Harry Met Sally director Rob Reiner and his wife, Michele Singer Reiner, after their murders. "Oh how we will miss this man," Ryan, 64, wrote via Instagram on Wednesday, December 17, sharing a throwback photo with the late director. "Thank you, Rob and Michele, for the way you believe in true love, in fairy tales, and in laughter. Thank you for your faith in the best in people, and for your profound love of our country." Ryan starred as Sally in When Harry Met Sally, opposite Billy Crystal's Harry. Rob directed the film, even changing the ending once he met Michele.