Article continues below advertisementRob Reiner and wife Michele were apparently at their limit when it came to their son Nick's drug problems.The couple was murdered at their Los Angeles mansion on December 14 - allegedly by Nick - following a "very loud argument" the three had at Conan O'Brien's holiday party the evening prior.According to a source, the filmmaker and his wife were reportedly flummoxed over their son's issues and didn't know where else to turn to shortly before they were killed.