The Handmaid's Tale cast is booked and busy with new projects - including the Testaments spinoff - after the Hulu series came to a shocking end. The Handmaid's Tale universe was brought to life when Hulu adapted Margaret Atwood's 1985 novel of the same name in 2017. Atwood's dystopian universe followed a future where low fertility rates have led women to be assigned to men for bearing children. Elisabeth Moss, Yvonne Strahovski, Madeline Brewer, Dowd, O-T Fagbenle, Max Minghella, Samira Wiley and Amanda Brugel have led the cast since the show premiered in 2017.