Jamie-Lynn Sigler is returning to TV after a three-year break to play a Grey's Anatomy doctor with multiple sclerosis. "If you told me 20 years ago that I would play a role on one of my favorite shows, not having to hide my MS but having it inspire a story, I would have never believed you," she wrote via Instagram on Thursday, December 11. "For anyone out there... your story isn't over yet." Deadline confirmed that Sigler, 44, will appear in the January 15, 2026, episode of the hit ABC series. She will play urologist Dr. Laura Kaplan, who is living with multiple sclerosis.