While Supernatural is sadly ending its long-running tenure on Netflix later this month, it's already been given a new life on Amazon Prime Video. The wildly popular fantasy-drama series stars Jensen Ackles and Jared Padalecki as demon hunters Dean and Sam Winchester, as we follow their many adventures and exploits chasing monsters while being frequently helped by the Angel Castiel (Misha Collins). The show just debuted on Prime Video, and Watch With Us thought we'd put together a breakdown of the show's most unmissable episodes. Here are our picks for five essential episodes from Supernatural. Netflix Will Lose This Fan-Favorite CW Show in December - Where to Stream It Next 1. 'Swan Song' (Season 5, Episode 22) The final episode of season 5, "Swan Song" was meant to be the series' finale, before series showrunner Eric Kripke was replaced by executive producer Sera Gamble. Still, "Swan Song" handily manages to be one of the show's very best offerings. Sam and Dean team up with their brother Adam (Jake Abel) and together they battle a demon named Michael, who they've allowed to enter Adam's body. The episode concludes with them trapping both Lucifer and Michael, while Chuck's true identity is hinted at. Fans love this episode as it provides an immensely satisfying conclusion to several storylines from the prior two seasons, while being filled with entertaining action, humor and tragedy. While you need to watch the previous seasons to enjoy it, it's got truly nail-biting moments as well as scenes that will make you cry. 2. 'Lazarus Rising' (Season 4, Episode 1) This makes our list in part for being the first appearance of Castiel, played by Misha Collins, who would go on to be an integral and beloved character on Supernatural. Castiel brings Dean back from Hell after being dead and buried for months, and he, Sam and Bobby (Jim Beaver) spend a good chunk of the episode's runtime trying to figure out how he came back. Assuming it to be the work of a Demon, they instead encounter Castiel, who quickly becomes the show's third lead. This episode is very emotionally satisfying on top of being an epic introduction for a great character. Plus, it shakes things up by adding angels into a series already heavily focused on demons, which thus changes the trajectory of the story. 3. 'Baby' (Season 11, Episode 4) This is a classic gimmick episode, but it's incredibly creative. The entirety of "Baby" is shot from the perspective of the brothers' car, named Baby. The 1967 Chevrolet Impala serves as the brothers' only home, and the episode follows the brothers going about their usual entity-hunting activities, with scenes taking place either inside the car or just outside of it - sometimes, the car isn't nearby at all. This episode is inventive and exciting in the way it captures "natural" moments between Sam and Dean and gives their relationship a whole new depth. The story arc is also tied together beautifully, creating an episode of TV that is both aesthetically interesting and narratively gratifying. 4. 'Changing Channels' (Season 5, Episode 8) Supernatural is notable for not just being a good drama, but occasionally featuring some genuinely hilarious comedy episodes. In particular, "Changing Channels' sees Sam and Dean face off against an old enemy named the Trickster, who sends the brothers into TV. There, they find themselves immersed in episodes of Grey's Anatomy and Knight Rider, as well as an ad for genital herpes medication. In addition to being laugh-out-loud funny, "Changing Channels" also brings some massive plot developments as well, with the Trickster's true nature revealed, and Sam and Dean learning what they have to do to fight Lucifer and Michael. 5. 'The French Mistake' (Season 6, Episode 15) Another entertaining stunt episode, "The French Mistake" finds the brothers pulled into a parallel universe where they are suddenly the actors who play them: Jared Padalecki and Jensen Ackles on the set of Supernatural. In Supernatural's fictional version of Supernatural, Sam and Dean can't act, they use sets never seen on the show and Jared has a pet alpaca. 5 Best Prime Video Shows of 2025 So Far, Ranked An insanely meta episode and delightfully tongue-in-cheek, fans loved how the show poked fun at itself and its actors in a way that was both funny and smart, and yet still somehow managed to fit nicely into the brothers' story. Stream Supernatural now on Prime Video.