Christina Applegate: 'I miss who I was before I got sick' Christina Applegate - who was diagnosed with multiple sclerosis in 2021 - admitted it was "like a knife to the heart" when her 14-year-old daughter Sadie shared how difficult she finds it coping 31 July 2025 Christina Applegate was devastated when her daughter told her she misses "who you were before you got sick".