Zendaya Eddy Chen/HBO Euphoria fans aren't the only ones who wanted answers about when the show would return - the cast wanted to know too before the release date was announced. The HBO series, which premiered in June 2019, follows troubled high school student Rue (Zendaya) as she struggles to remain sober after rehab. The ensemble cast includes Hunter Schafer, Alexa Demie, Jacob Elordi, Sydney Sweeney, Maude Apatow, Colman Domingo and more.