Amy Schumer has been candid over the past couple of years about her experience using weight loss drugs on her health journey. In March 2025, Schumer explained that three years ago she tried GLP-1 medication Wegovy - and did not have a pleasant time on it. "I was puking. I couldn't handle it," Schumer said in a video shared via Instagram. "I don't know if they've changed the formula, whatever. But anyway, I went on this Telehealth meeting with Midi Health, and it was cheap. I wanted to try it myself 'cause I wanted to recommend it to my friends who are nurses and teachers.