The Golden Girls followed four women living out their golden years under one roof in Miami, eating cheesecake and cracking jokes that still make fans laugh. While Bea Arthur, Betty White, Rue McClanahan and Estelle Getty pulled in fans week after week as main characters, Dorthy, Rose, Blanche and Sophia, respectively, the show also boasted a slew of A-list guest stars. Icons like Dick Van Dyke, George Clooney (pre-ER) and Debbie Reynolds all made cameos on the NBC sitcom during its seven-season run.