Kelsey Grammer has had lasting success in the entertainment industry - his portrayal of Dr. Frasier Crane is one of the longest-running roles in TV history - but he has also faced numerous tragedies over the years. Grammer was only 13 years old when his father was shot and killed. Six years later, he faced another unimaginable loss when his younger sister, Karen, then 18, was raped and murdered. In 1980, Grammer faced two more familial deaths, losing his younger half-brothers in a scuba diving incident.