Malcolm in the Middle is being revived with a four-part series - but which stars are and aren't reprising their roles? The original series, which ran on Fox from 2000 to 2006, starred Jane Kaczmarek, Bryan Cranston, Christopher Masterson, Justin Berfield, Erik Per Sullivan and Frankie Muniz. Nearly two decades after Malcolm in the Middle came to an end, news broke that Disney+ picked up a revival series.