Zachary Quinto has a big medical mystery on his hands in an upcoming episode of Brilliant Minds, which introduces Jane Krakowski's chilling character. In Us Weekly's first look at the episode, which airs on Monday October 13, Oliver Wolf (Quinto) visits a patient who needs his medical help. Krakowski's character is seen largely not speaking while Oliver examines the bruises on her body. "We are here to assess you," he says. "Can you tell us where you are? What happened? Can you look at my pen light and follow it with your eyes?" Arianna (Krakowski) isn't able to follow the light, which is when Oliver noticed a subtle message his patient was able to leave with some paper cranes. They were arranged on the floor to spell the word "help," which concerned the doctor. Us Investigates How the New Slate of Medical TV Shows Differ From Each Other According to the official character description, Krakowski plays "a high-powered businesswoman who fights her conservatorship despite her family's growing concerns." Brilliant Minds, which premiered in September 2024, is inspired by the Oliver Sacks books The Man Who Mistook His Wife for a Hat and An Anthropologist on Mars. The show follows a neurologist and his team of interns as they tackle challenging neurology cases while dealing with their own relationships and mental health. Pief Weyman/NBC The NBC procedural has been met with critical success, and Quinto, 48, is also making history. Oliver is the first openly gay character to lead a network medical series. "I think the thing for me that is so significant about that is that it's not significant at all. Actually, it's not significant to the character," Quinto said on The Drew Barrymore Show in December 2024. "It's an aspect of who the character is and NBC was really open to and invested in this story, the value of this story in our contemporary culture and the conversations that are happening today in the society." Quinto noted that the role meant "so much" to him because it is based on Sacks, who died in 2015. Best Medical TV Shows of All Time: 'ER,' 'Grey's Anatomy' and More "He lived and worked primarily in the mid-20th century, and he was a gay man himself and was celibate for 35 years of his life. When I found that out, I was like, 'If you're not somehow called to the clergy or living a life that restricts that, why would you ever make a choice like that?'" the actor recalled. "Then the more I learned about him and the more I read about him and the more that I observed why someone would make that decision, it became clear to me that it was because he didn't feel he could be authentically himself and be afforded the same opportunities in his field of medicine. He knew he was designed to change the field of medicine, which he did." After reading about the inspiration for Brilliant Minds, Quinto believed the role would be "an honor" to take on. "The tragedy of his life was that he felt like if he brought that part of himself into his work, he would have been denied those opportunities," he explained. "So for me to be in this situation now - a generation later - and to be an openly gay man who's leading this show and who's telling this story, it's such an opportunity to honor the original man himself, Oliver Sacks." He concluded: "And to say how grateful I am that I don't have to cut that part of myself off in order to enjoy a life of fulfillment and success." Brilliant Minds airs on NBC Mondays at 10 p.m. ET. New episodes stream the next day on Peacock.