Grey's Anatomy built up anticipation for its season 22 premiere with warnings of character deaths and onscreen surprises - so who actually survived the hospital explosion? The ABC series returned on Thursday, October 9, and picked up moments after a part of the ER was destroyed. When viewers were last in Grey Sloan Memorial Hospital, Piper Perabo played a mother of a patient who brought a highly flammable acetylene tank into the operating room to force Amelia (Caterina Scorsone) to perform a high-risk surgery to save her daughter.