Jennifer Aniston doesn't see a world where the Friends cast could have a reunion without Matthew Perry. "It would be literally, physically impossible," Aniston, 56, said of doing a potential Friends revival or remake without Perry in an interview with Harper's Bazaar published on Wednesday, October 8. Perry died of an accidental ketamine overdose at age 54 in October 2023. Before his tragic passing, the actor was candid about his struggles with depression and substance abuse. "It's heartbreaking that he had so many demons," Aniston reflected on her late costar.