The explosion at Grey Sloan Memorial Hospital could mean not every cast member is returning to Grey's Anatomy for season 22. During the May 2025 finale of the hit ABC series, Piper Perabo played a mother of a patient who brought a highly flammable acetylene tank into the operating room to force Amelia (Caterina Scorsone) to perform a high-risk surgery to save her daughter. The hostage situation included interns Simone (Alexis Floyd) and Adams (Niko Terho) at risk while Meredith (Ellen Pompeo) tried to save them before it was too late.