Jensen Ackles and Jared Padalecki in 'Supernatural' The CW Jared Padalecki and Jensen Ackles won Us over when they played brothers on Supernatural - and they have remained booked and busy since The CW show came to an end. Padalecki and Ackles played the monster-hunting duo from 2005 to 2020. After appearing in over 300 episodes of the hit series, Padalecki exclusively told Us Weekly that he felt he would "never really say goodbye" to his character. "We really have become a family," he said at the time about the journey. "Over 15 years, we've cut the fat.