Matthew Perry Nick Rood/Young Hollywood/Getty Images Two months after Matthew Perry died at age 54 in October 2023, his death was ruled an accident. That ruling proved to be far from the end of the story. A December 2023 toxicology report concluded that Perry died from "the acute effects of ketamine." The report noted that Perry had been receiving regular ketamine infusions to treat depression and anxiety, but his last infusion had taken place more than a week before his death. The discrepancy left room for questions about how and why Perry had ketamine in his system when he died.