Serena Williams sheds 30lbs with weight-loss medication Tennis legend Serena Williams has lost over 30lbs with the aid of weight-loss medication. 21 August 2025 Serena Williams has lost over 30lbs with the aid of weight-loss medication. Serena Williams has been using weight-loss medication The tennis champion found it hugely "frustrating" when she was unable to get her pre-pregnancy physique back after giving birth to daughter Olympia in 2017 and faced similar struggles when her second daughter Adira was born in August 2023.