One magic mushroom 'trip' changes the brain A single magic mushroom 'trip' is enough to physically change the brain for several weeks. 9 May 2026 Taking magic mushrooms just once may be enough to physically alter the brain for weeks, scientists have revealed. Magic mushrooms can have a lasting impact on the brain Researchers say a single high-dose "trip" using psilocybin - the psychedelic compound found in magic mushrooms - boosted emotional awareness, increased brain activity and left volunteers feeling happier and more optimistic long after the experience ended.