View gallery Image Credit: Everett Collection / Shutterstock When Grey's Anatomy premiered on March 27, 2005, TV was never the same. Fans immediately fell in love with Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, George O'Malley, Derek Shepherd, Miranda Bailey and more. Over the years, Grey's Anatomy has shocked us with jaw-dropping twists, made us cry over heartbreaking deaths and breakups, and made us laugh and smile during the show's happiest moments.