Instagram/Cathy Cavadini & Tara Str Celebrity The original Powerpuff Girls voice cast reunites for a heartwarming video, 21 years after the show ended. See Blossom, Bubbles, Buttercup & Professor Utonium... May 4, 2026 AceShowbiz - More than 21 years after the original run of The Powerpuff Girls ended, the beloved voice cast has come together again, delighting fans with a heartwarming reunion video. This iconic Cartoon Network series remains a staple in animation history, celebrated for its unique blend of superhero action and family-friendly humor nearly three decades since its debut.