20th Century Studios The Devil Wears Prada 2 is doing big numbers at the box office already. The highly anticipated sequel to the 2006 hit film, starring Meryl Streep, Anne Hathaway, Emily Blunt and Stanley Tucci, brought in over $77 million at the domestic box office in its opening weekend. The movie had a big global box office debut The movie opened globally at $233 million. How the sequel's box office compares to the original film It will need to surpass $535 million to beat out the run of the first movie, which brought in $326.5 million (before inflation adjustment) in 2006, per The Wrap.