TMDb/Grey's Anatomy TV Grey's Anatomy returns April 30! Don't miss the penultimate episode and May 7 finale. Cliffhangers, secrets, and farewells await before Season 22 ends. April 10, 2026 AceShowbiz - Grey's Anatomy is currently on a break, leaving fans eager to know when new episodes will air and what drama awaits before season 22 concludes. The medical drama is set to return to ABC on Thursday, April 30, with the penultimate episode of the season. This episode will lead into the season finale scheduled for May 7, which promises significant developments and farewells.