Grey's Anatomy has been going through a surprising amount of cast exits and onscreen deaths. The medical drama, which premiered in 2005, is focused on the personal and professional lives of surgical interns, residents and attendings at the fictional Seattle Grace Hospital a.k.a Seattle Grace Mercy West Hospital a.k.a Grey Sloan Memorial Hospital. Due to the nature of the show, Grey's Anatomy has become known for its wild twists that often result in cast exits.