Supernatural actress Carrie Anne Fleming has sadly passed away. According to a post made by her co-star Jim Beaver on Facebook, the actress who played Bobby Singer's wife Karen has tragically lost her battle with cancer. He wrote in the heartbreaking note that he'd lost a second "soul mate" after the death of his wife, Cecily Adams, in 2004: "To find a soul mate once in life is something of a miracle. To find one twice is almost unimaginable. To love and be loved is a pearl above price, but such pearls do come more than once or twice to the lucky.