Conan O'Brien and his wife, Liza Powel O'Brien, have been by each other's side for more than two decades. The pair first crossed paths in 1999 while filming a Late Night With Conan O'Brien segment at the advertising agency where she worked as a copywriter. "I immediately start talking to her [Liza], and then I'm not even trying to be funny ... I'm just trying to find out more about this woman," O'Brien recounted on "The Michelle Obama Podcast" in September 2020. "Then I left the room after this 20-minute conversation with only her ... We were breaking down the equipment, and she walks out.