Most of the original Scrubs cast is reprising their roles for the highly anticipated revival - but who else is new to the show? Scrubs, which originally aired from 2001 to 2010, followed the lives of employees at the fictional Sacred Heart Hospital. The hit series starred Zach Braff, Sarah Chalke, Donald Faison, Judy Reyes, Neil Flynn, Ken Jenkins and John C. McGinley before it was brought back for a ninth season titled Med School. The show's final season moved the setting to a medical school to introduce new characters.