Christina Applegate confined to her bedroom amid health struggles Christina Applegate has opened up about her experience of living with MS. 25 February 2026 Christina Applegate is largely confined to her bedroom amid her battle with multiple sclerosis (MS). Christina Applegate was diagnosed with the condition in 2021 The 54-year-old actress went public with her diagnosis in 2021, and she's now explained how it's impacted her day-to-day life.