Charmed fans have mourned the deaths of some of the show's most beloved cast members over the years. The supernatural drama series - which aired between 1998 and 2006 - was centered around sisters Prue (Shannen Doherty), Piper (Holly Marie Combs) and Phoebe Halliwell (Alyssa Milano) using their magical abilities as the "Power of Three" to protect innocents. Rose McGowan later joined Charmed as Piper and Phoebe's half-sister Paige Matthews, following Doherty's departure at the end of season 3. Despite the show's notorious behind-the-scenes drama, the Charmed community came together to mourn Doherty when she died at age 53 in July 2024 after battling cancer. "A true lion heart. What a warrior," McGowan wrote via Instagram in tribute to Doherty at the time. "Your daddy is holding his best girl now. Love to your mama, your dog and all who love you fiercely." Shannen Doherty and Eric Dane Getty Images (2) Over the years, the Charmed fanbase has also experienced the deaths of Eric Dane and Julian McMahon, who played Jason Dean and Cole Turner, respectively. Keep scrolling for a look back at stars from the original Charmed who we lost too soon. Shannen Doherty Viacom/Courtesy Everett Collection Shannen Doherty was one-third of the original "Power of Three" trio along with Alyssa Milano and Holly Marie Combs. She left Charmed at the end of season 3 amid reports of backstage conflict between her and Milano. The Beverly Hills, 90210 alum announced her breast cancer diagnosis in March 2015 and initially went into remission before the disease returned in 2020. Doherty shared in June 2023 that the cancer had spread to her brain. On July 13, 2024, Doherty's publicist Leslie Sloane confirmed to Us Weekly that the actress had died at age 53. "It is with a heavy heart that I confirm the passing of actress Shannen Doherty. On Saturday, July 13, she lost her battle with cancer after many years of fighting the disease," Sloan told Us. "The devoted daughter, sister, aunt and friend was surrounded by her loved ones as well as her dog, Bowie. The family asks for their privacy at this time so they can grieve in peace." All of the Charmed actresses who were part of the "Power of Three" in the original series - including Milano - paid tribute to Doherty following her death. "It's no secret that Shannen and I had a complicated relationship, but at its core was someone I deeply respected and was in awe of," Milano told Us at the time. "She was a talented actress, beloved by many and the world is less without her. My condolences to all who loved her." Remembering Julian McMahon and Shannen Doherty's Romance After Deaths Rose McGowan remembered Doherty as a "warrior" with a "lion heart" while Holly Marie Combs admitted that she never expected to lose Doherty so soon. "I've had a little bit of time to reflect on that and how everything worked out," Combs said on her"House of Halliwell" podcast in July 2024. "I think she did as much as she could in the time that she had, but we did think we had more time. That's the really sad part. We had big, big plans for this year. She didn't think she was going anywhere anytime soon." Doherty was married three times - to Ashley Hamilton from 1993 to 1994, then to Rick Salomon from 2002 to 2003 and Kurt Iswarienko from 2011 to 2024 - but had no children. Eric Dane Viacom Future Grey's Anatomy star Eric Dane had an early career breakthrough with a recurring role on Charmed as Phoebe's boss-turned-boyfriend Jason Dean. In April 2025, Dane went public with his ALS diagnosis. Per the Mayo Clinic, ALS is a nervous system disease that impacts nerve cells in both the brain and spinal cord and causes a progressive loss of muscle control. "I have been diagnosed with ALS," he told People at the time. "I am grateful to have my loving family by my side as we navigate this next chapter." Dane was chosen as the Advocate of the Year Award at the ALS Network's Champions for Cures and Care Gala in January 2026 but could not accept in person "due to the physical realities of ALS," the organization said. A spokesperson for Dane confirmed to Us Weekly on February 19, 2026, that the Charmed alum died at age 53. (He was survived by his two daughters, Billie and Georgia, from his marriage to Rebecca Gayheart.) "[Eric] will be deeply missed, and lovingly remembered always," his rep said. "Eric adored his fans and is forever grateful for the outpouring of love and support he's received. The family has asked for privacy as they navigate this impossible time." Alyssa Milano - who costarred with Dane on Charmed and also briefly dated him - looked back on their long friendship following the announcement of his death. "I can't stop seeing that spark in Eric's eye right before he'd say something that would either make you spit out your drink or rethink your entire perspective," Milano wrote via Instagram. "He had a razor-sharp sense of humor. He loved the absurdity of things. He loved catching people off guard. 'Charmed' Cast: Wher