The night ... was March 27, 2005. Television titan Shonda Rhimes knew what she had just created - but audiences still had no idea. The Grey's Anatomy pilot introduced several characters, including the show's protagonist, legacy surgical resident Meredith Grey (Ellen Pompeo). Spunky, undoubtedly intelligent and full of heart, the show wouldn't survive without its titular character - but the ensemble is what keeps viewers tuning in 15 years later. That's why it hits fans hard every time a character gets the boot.