Hollywood is mourning the loss of Eric Dane. On Thursday, the family confirmed that the 53-year-old actor died following a battle with amyotrophic lateral sclerosis or ALS, a neurodegenerative disease that impacts nerve cells in the brain and spinal cord. Many celebrities are now taking to social media to honor Eric, including Ashton Kutcher, who starred alongside him in the 2010 movie Valentine's Day. He wrote on X (Twitter): "The Franklin strip fanatics fantasy football league will miss Mr. Eric Dane. We know you'll be watching from the booth. Miss you, buddy. Let's keep fighting the fight to solve ALS." The Franklin strip fanatics fantasy football league will miss Mr. Eric Dane. We know you'll be watching from the booth. Miss you, buddy. Let's keep fighting the fight to solve ALS. pic.twitter.com/00TtwmQHAK - ashton kutcher (@aplusk) February 20, 2026 Alyssa Milano, who worked with Eric on Charmed, remembered the love he had for his wife, Rebecca Gayheart, and their two daughters, Billie and Georgia: "I can't stop seeing that spark in Eric's eye right before he'd say something that would either make you spit out your drink or rethink your entire perspective. He had a razor-sharp sense of humor. He loved the absurdity of things. He loved catching people off guard. And when it came to his daughters and Rebecca, everything in him softened. He carried them with him even in rooms where they weren't present. You could see it in the way his voice changed when he said their names. A breathtakingly beautiful family. The spark. The mischief. The tenderness he kept guarded but never totally hidden. He convinced me to get my pixie cut and my nose piercing. He also was with me on the walk when we found Lucy, my beloved rescue chihuahua. He called me 'Milano,' as if it was the only part of my name that mattered. My heart is with the people who were lucky enough to be his home." View this post on Instagram A post shared by Alyssa Milano (@milano_alyssa) His Redeeming Love co-star Nina Dobrev expressed on Instagram Stories: "Heartbroken to hear about the passing of Eric. He was warm, generous, prepared, and so passionate about what he did. He led with kindness and made everyone on our set feel seen." Maria Shriver, who is publishing his memoir Book of Days: A Memoir in Moments under her Penguin Random House publishing imprint, The Open Field, vowed to honor his story: "I'm heartbroken by this devastating news about Eric Dane. What a tragedy. He was so heroic the way he handled his diagnosis. He used his voice to let the world know what it was like living with ALS. I was honored he chose my publishing imprint to publish his memoir. He told me he wanted his family to know how much he loved them, and he wanted to leave them a story they could be proud of. My love goes out to his family, and to all those battling this cruel disease, as well as all those caring for somone battling it. Godspeed, Eric. It was an honor to know you, and we will honor your story." View this post on Instagram A post shared by Maria Shriver (@mariashriver) Eric's onscreen wife in Euphoria, Paula Marshall, shared a sweet picture of the pair to IG Stories, adding: "RIP Mr Dane" (c) Paula Marshall/Instagram The creator of Euphoria, Sam Levinson, said being Eric's friend "was a gift" in a statement to Variety: "I'm heartbroken by the loss of our dear friend Eric. Working with him was an honor. Being his friend was a gift. Eric's family is in our prayers. May his memory be for a blessing." Frank Grillo, who starred in Little Dixie with Eric, wrote on Instagram: "My heart is broken. We lost a good man @realericdane who I had the pleasure of sharing the screen with. We became pals and laughed often. My prayers go out to his beautiful family. See you on the other side brother." Eric's Bad Boys: Ride or Die co-star Alexander Ludwig expressed: "Ugh this hurts so much. Will miss you Eric and loved our time together. You were a joy to work with." Travis Van Winkle shared that he "learned so much from Eric" while working on The Last Ship together, adding: "He was a great man. I'm sad to see him go in this way. I'm sending love to his family. Thanks for the memories my friend." Eric was clearly such a bright light to all those who knew and loved him. Check out more tributes to Eric (below): View this post on Instagram A post shared by John Stamos (@johnstamos) View this post on Instagram A post shared by Paul Walter Hauser (@paulwhausergram) View this post on Instagram A post shared by Martin Lawrence (@martinlawrence) Eric Dane was a good man. We weren't lifelong friends, but we crossed paths enough for me to know his strength and his heart. ALS is merciless. My thoughts are with his family. Rest easy ???? pic.twitter.com/mMDOxxiYlE - Robert Patrick ???????? (@robertpatrickT2) February 20, 2026 View this post on Instagram A post shared by Jensen Ackles (@jensenackles) (c) Selma Blair/Instagram (c) Mädchen Amick/Instagram Rest in peace, Eric... [Image via MEGA/Nic