Chrissy Teigen, Matthew Perry, and Sharon Osbourne. Getty Images (3) Celebrities like Matthew Perry, Chrissy Teigen and others have been open about using ketamine infusion therapy to help treat mental health conditions. According to the United States Drug Enforcement Administration (DEA), ketamine is a "dissociative anesthetic that has some hallucinogenic effects" and "can induce a state of sedation, immobility, relief from pain, and amnesia.