Savannah Guthrie's strong bond with sister Annie Guthrie is one that many parents dream of. "My sister is by far the most wise, intelligent, thoughtful, creative, generous and profoundly original person I know," Savannah wrote in her 2024 book, Mostly What Goes Does: Reflections on Seeking and Finding His Love Everywhere. "She is my forever partner in life." That bond has been put on display even more after Savannah and Annie's mom, Nancy Guthrie, was reported missing on February 1, 2026.