Watch: Christina Applegate Talks "Fatalistic" Depression Amid Multiple Sclerosis BattleChristina Applegate is navigating a new chapter of her health journey. The Married With Children alum-who shared her multiple sclerosis (MS) in 2021-recorded the latest episode of her MesSy podcast with Jamie-Lynn Sigler from her hospital room, where she's currently being treated for a kidney infection. "I'm not doing a podcast from the hospital because I felt like doing one from the hospital was an awesome idea," Christina explained on the Aug. 5 episode.