Catherine O'Hara was candid about being diagnosed with situs inversus in the years before her death. O'Hara learned later in life that she was born with the rare condition, when a person's major thoracic and abdominal organs are mirrored from their normal positions, per the National Institutes of Health. During a 2020 appearance on Virtual Happy Hour, O'Hara jokingly called herself a "freak" when she learned she had the condition more than two decades ago. "I love Western medicine, I just don't want to be a part of it.