There's been several instances when a star's real-life health issues contributed to their fictional counterpart. Jamie-Lynn Sigler announced in 2016 that she was diagnosed with multiple sclerosis (MS) when she was 20 years old. MS is an autoimmune disease that damages the nerve cells in the brain and spinal cord. In January 2026, Sigler played a doctor battling the same condition on Grey's Anatomy. "Prior to this [opportunity], I was always trying to say, 'We can work around [my MS]. Don't worry, there's things that we can do to hide it.