Alyssa Milano and Jeannie Mai are ready to spark a conversation about perimenopause. "One of the symptoms is being forgetful. Another one of the symptoms is not having the calmness that you had in your 30s," Mai, 47, exclusively shared with Us Weekly at the Los Angeles premiere of the upcoming 4-part docuseries Balance: A Perimenopause Journey on January 13. "Sometimes it looks like panic attacks or anxiety attacks. Sometimes it looks like an insecurity within yourself.